INSUBCONTINENT EXCLUSIVE:
Sanofiis also working on amRNACOVID-19 vaccine candidate with Translate
BioSanofi will invest about 400 million euros ($476.4 million) in research and development of
next-generation vaccines using mRNA technologies, which proved their efficiency in the Pfizer and Moderna COVID-19 vaccines.The French
drug giant and its British counterpart GlaxoSmithKline surprised investors and customers late last year when they announced a one-year
delay to the launch of their joint COVID vaccine, based on a more conventional technology.Sanofi has since pledged to help Pfizer and
Moderna manufacture COVID-19 shots in an effort to help meet the huge demand for the U.S
drugmaker's doses.Sanofi added on Tuesday that its "mRNA Center of Excellence" will bring together around 400 employees, and was
expected to produce a minimum of six clinical candidates by 2025."During the COVID-19 pandemic, mRNA technologies demonstrated potential
to deliver new vaccines faster than ever before", said Jean-Francois Toussaint, global head of R-D at Sanofi Pasteur."However, key areas
of innovation such as thermostability and tolerability improvements will be critical to unlock the applications of mRNA in routine
vaccination against a broader set of infectious diseases and across all ages," he added.The mRNA technology has proven both effective and
safe so far in the vaccine response to COVID-19, including in response to the virus' variants.The latest one, the Delta variant first found
in India, is spreading at a fast rate around the world, prompting governments to accelerate their vaccinations programs.French Health
Minister Oliver Veran said on Tuesday that the Delta variant represented some 20 percent of COVID cases in France.Sanofi is also working on
a mRNA COVID-19 vaccine candidate with U.S
company Translate Bio, for which it has started clinical trials.The two groups, which have been collaborating since 2018, have also started
a Phase I clinical trial earlier this year evaluating an mRNA-based investigational vaccine against seasonal influenza.Last
month, Sanofi and GlaxoSmithKline launched a late-stage human trial for a recombinant COVID-19 vaccine candidate, which they hope to get
approved by the end of 2021.That vaccine is based one of the most established technologies in vaccines - used against the human
papillomavirus, hepatitis B and pertussis among other pathogens - which aims to introduce lab-made proteins into the body to prod the immune
system into developing a targeted defence against the novel coronavirus.
